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Article

The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.

Genetics - 1 Jan 2011

Wiltrout Mary Ellen, Walker Graham C

Abstract excerpt

A cell's ability to tolerate DNA damage is directly connected to the human development of diseases and cancer. To better understand the processes underlying mutagenesis, we studied the cell's reliance on the potentially error-prone translesion synthesis (TLS), and an error-free, template-switching pathway in Saccharomyces cerevisiae. The primary proteins mediating S. cerevisiae TLS are three DNA polymerases...

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Identifiers

PMID: 20980236
DOI: 10.1534/genetics.110.124172
PMCID: PMC3018306

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The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.PMID 20980236Read ↗

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.Semantic proximity Read ↗

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.Semantic proximity Read ↗

The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.Semantic proximity Read ↗

Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA.Semantic proximity Read ↗

The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control.Semantic proximity Read ↗

A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.Semantic proximity Read ↗

Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1pSemantic proximity Read ↗

Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.Semantic proximity Read ↗

The catalytic function of the Rev1 dCMP transferase is required in a lesion-specific manner for translesion synthesis and base damage-induced mutagenesis.Semantic proximity Read ↗

A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ.Semantic proximity Read ↗

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Semantic proximity Read ↗

The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

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