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Article

APOE DNA methylation is altered in Lewy body dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2018

Tulloch Jessica, Leong Lesley, Chen Sunny, Keene C Dirk, Millard Steven P, Shutes-David Andrew, Lopez Oscar L, Kofler Julia, Kaye Jeffrey A, Woltjer Randy, Nelson Peter T, Neltner Janna H, Jicha Gregory A, Galasko Douglas, Masliah Eliezer, Leverenz James B, Yu Chang-En, Tsuang Debby

Abstract excerpt

INTRODUCTION: Inheritance of the ε4 allele of apolipoprotein E (APOE) increases a person's risk of developing both Alzheimer's disease (AD) and Lewy body dementia (LBD), yet the underlying mechanisms behind this risk are incompletely understood. The recent identification of reduced APOE DNA methylation in AD postmortem brains prompted this study to investigate APOE methylation in LBD. METHODS: Genomic DNA from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29544979
DOI: 10.1016/j.jalz.2018.02.005
PMCID: PMC6050144

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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