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Article

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology.

Neurology - 18 Sept 2018

Dickson Dennis W, Heckman Michael G, Murray Melissa E, Soto Alexandra I, Walton Ronald L, Diehl Nancy N, van Gerpen Jay A, Uitti Ryan J, Wszolek Zbigniew K, Ertekin-Taner Nilüfer, Knopman David S, Petersen Ronald C, Graff-Radford Neill R, Boeve Bradley F, Bu Guojun, Ferman Tanis J, Ross Owen A

Abstract excerpt

OBJECTIVE: To evaluate whether APOE ε4 is associated with severity of Lewy body (LB) pathology, independently of Alzheimer disease (AD) pathology. METHODS: Six hundred fifty-two autopsy-confirmed LB disease (LBD) cases and 660 clinical controls were genotyped for APOE. In case-control analysis, LBD cases were classified into 9 different groups according to severity of both LB pathology (brainstem, transitional,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30143564
DOI: 10.1212/WNL.0000000000006212
PMCID: PMC6161556

Genes

APOE

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