Article
Genetic evidence that the Lewy body variant is indeed a phenotypic variant of Alzheimer's disease.
Brain and cognition - 1 Aug 1995
Katzman R, Galasko D, Saitoh T, Thal L J, Hansen L
Abstract excerpt
Lewy Body Variant (LBV) patients present as Alzheimer's disease (AD) clinically; about two-thirds also have mild extrapyramidal features. At autopsy, neocortical and brain stem Lewy bodies are present in addition to changes diagnostic of AD. We have found that the Apolipoprotein E4 allele is a major genetic risk factor for LBV as it is for "pure AD," in contrast to subjects with diffuse Lewy body disease or...
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