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Article

Glia-specific APOE epigenetic changes in the Alzheimer's disease brain.

Brain research - 1 Nov 2018

Tulloch Jessica, Leong Lesley, Thomson Zachary, Chen Sunny, Lee Eun-Gyung, Keene C Dirk, Millard Steven P, Yu Chang-En

Abstract excerpt

The apolipoprotein E gene (APOE) is the strongest genetic risk factor for developing Alzheimer's disease (AD). Our recent identification of altered APOE DNA methylation in AD postmortem brain (PMB) prompted this follow-up study. Our goals were to (i) validate the AD-differential methylation of APOE in an independent PMB study cohort and (ii) determine the cellular populations (i.e., neuronal vs. non-neuronal) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30081037
DOI: 10.1016/j.brainres.2018.08.006
PMCID: PMC6388639

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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