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Article

Gene of the month: GATA3.

Journal of clinical pathology - 1 Dec 2023

Qiang Zekai, Jubber Ibrahim, Lloyd Kirsty, Cumberbatch Marcus, Griffin Jon

Abstract excerpt

GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is...

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Identifiers

PMID: 37726118
DOI: 10.1136/jcp-2023-209017

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