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Article

ZNF50 3/ Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

3 Mar 2017

Abstract excerpt

Significance Transcription factor GATA3 has emerged as one of top three altered genes in mammary tumors. In breast cancer, GATA3 expression has been associated with an estrogen receptor (ER)-positive (ER + /luminal) phenotype. ER + tumor cells resemble more differentiated cells, and affected patients are more responsive to therapy and have overall better survival outcomes. Loss of GATA3 correlates with ER − ,...

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PMID: 28258171
DOI: 10.1073/pnas.1701690114

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