Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females

21 Nov 2013

Abstract excerpt

The maintenance of key germline derived DNA methylation patterns during preimplantation development depends on stores of DNA cytosine methyltransferase-1o (DNMT1o) provided by the oocyte. Dnmt1o(mat-/-) mouse embryos born to Dnmt1(Δ1o/Δ1o) female mice lack DNMT1o protein and have disrupted genomic imprinting and associated phenotypic abnormalities. Here, we describe additional female-specific morphological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24278026
DOI: 10.1371/journal.pgen.1003873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in FemalesPMID 24278026Read ↗

Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.Semantic proximity Read ↗

Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterningSemantic proximity Read ↗

Profound phenotypic variation among mice deficient in the maintenance of genomic imprints.Semantic proximity Read ↗

Sex-specific exons control DNA methyltransferase in mammalian germ cellsSemantic proximity Read ↗

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.Semantic proximity Read ↗

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Semantic proximity Read ↗

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated RegionsSemantic proximity Read ↗

Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.Semantic proximity Read ↗

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline.Semantic proximity Read ↗

Loss of maternal Trim28 causes male-predominant early embryonic lethality.Semantic proximity Read ↗

Dynamics of Dnmt1 Methyltransferase Expression and Intracellular Localization during Oogenesis and Preimplantation DevelopmentSemantic proximity Read ↗

DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.