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Article

Development of a column-switching LC-MS/MS method of tramadol and its metabolites in hair and application to a pharmacogenetic study.

Archives of pharmacal research - 1 May 2018

Yu Hyerim, Choi Minje, Jang Jung-Hee, Park Byoungduck, Seo Young Ho, Jeong Chul-Ho, Bae Jung-Woo, Lee Sooyeun

Abstract excerpt

Hair is a valuable specimen for monitoring long-term drug use. Tramadol is an effective opioid analgesic but is associated with risks such as drug dependence and unexpected toxicity arising from genetic differences in metabolism. However, few studies have been performed on the distribution of tramadol and its metabolites in hair. In the present study, a column-switching LC-MS/MS method was developed and fully...

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PMID: 29524157
DOI: 10.1007/s12272-018-1013-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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