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Article

Sequencing CYP2D6 for the detection of poor-metabolizers in post-mortem blood samples with tramadol.

Forensic science international - 1 Aug 2016

Fonseca Suzana, Amorim António, Costa Heloísa Afonso, Franco João, Porto Maria João, Santos Jorge Costa, Dias Mário

Abstract excerpt

Tramadol concentrations and analgesic effect are dependent on the CYP2D6 enzymatic activity. It is well known that some genetic polymorphisms are responsible for the variability in the expression of this enzyme and in the individual drug response. The detection of allelic variants described as non-functional can be useful to explain some circumstances of death in the study of post-mortem cases with tramadol. A...

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PMID: 26926096
DOI: 10.1016/j.forsciint.2016.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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