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Article

Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 1 Feb 2010

Chytil Lukás, Matousková Olga, Cerná Olga, Pokorná Pavla, Vobruba Václav, Perlík Frantisek, Slanar Ondrej

Abstract excerpt

A rapid and sensitive method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for enantiomeric determination of tramadol and its primary phase metabolite O-desmethyltramadol in human plasma has been developed. Tramadol hydrochloride-(13)C, d(3), was used as an isotopic labeled internal standard for quantification. The method involves a simple solid phase extraction. The analytes and internal...

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Identifiers

PMID: 20018572
DOI: 10.1016/j.jchromb.2009.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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