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Article

Metabolic ratios and SNPs implicated in tramadol-related deaths.

International journal of legal medicine - 1 Sept 2023

Aly Sanaa M, Hakim Florian, Richeval Camille, Hennart Benjamin, Gaulier Jean-Michel, Allorge Delphine

Abstract excerpt

Tramadol (TR) metabolism is performed by polymorphic enzymes that are influenced by genetic polymorphisms. Within this scope, the study presented here aimed to describe 41 genetic variants within CYP2D6, CYP2B6, and CYP3A4 genes in 48 cases of TR-related death that may be involved in the response to TR and to assess whether there is a correlation between these genetic variants and metabolic ratios (MRs). Blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37460702
DOI: 10.1007/s00414-023-03052-8

Genes

CYP2B6
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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