Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers.

Biopharmaceutics & drug disposition - 1 Dec 2007

Ardakani Yalda H, Rouini Mohammad-Reza

Abstract excerpt

By using a high-performance liquid chromatography method, the pharmacokinetics of the tramadol (T) and its three main metabolites, O-desmethyltramadol (M1), N-desmethyltramadol (M2) and O,N-didesmethyltramadol (M5) was studied in healthy male and female Iranian volunteers after oral administration of two 50 mg tramadol hydrochloride tablets. The related pharmacokinetic parameters such as C(max), T(max),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Analgesics, Opioid
Share to Area Under Curve

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Half-Life

Share to Phenotype

Share to Polymorphism, Genetic

Share to Sex Factors

Source

Identifiers

PMID: 17891748
DOI: 10.1002/bdd.584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers.PMID 17891748Read ↗

Assessment of tramadol pharmacokinetics in correlation with CYP2D6 and clinical symptoms.Semantic proximity Read ↗

Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.Semantic proximity Read ↗

Trends in Tramadol: Pharmacology, Metabolism, and Misuse.Semantic proximity Read ↗

Clinical pharmacokinetic registration file for NDA and ANDA procedures.Semantic proximity Read ↗

Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T.Semantic proximity Read ↗

Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection.Semantic proximity Read ↗

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol.Semantic proximity Read ↗

PharmGKB summary: tramadol pathway.Semantic proximity Read ↗

Metabolic ratios and SNPs implicated in tramadol-related deaths.Semantic proximity Read ↗

Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients.Semantic proximity Read ↗

Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype.Semantic proximity Read ↗

Role of Pharmacogenetics on Tramadol Pharmacokinetics: A Population Pharmacokinetic Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.