Article
Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.
Pharmacology research & perspectives - 1 Jul 2018
Haage Pernilla, Kronstrand Robert, Josefsson Martin, Calistri Simona, van Schaik Ron H N, Green Henrik, Kugelberg Fredrik C
Abstract excerpt
Tramadol is a complex drug, being metabolized by polymorphic enzymes and administered as a racemate with the (+)- and (-)-enantiomers of the parent compound and metabolites showing different pharmacological effects. The study aimed to simultaneously determine the enantiomer concentrations of tramadol, O-desmethyltramadol, N-desmethyltramadol, and N,O-didesmethyltramadol following a single dose, and elucidate if...
Topics
- Administration, Oral
- Adult
- Analgesics, Opioid
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP3A
- Genotype
- Humans
- Stereoisomerism
- Tramadol
- Young Adult