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Article

Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.

Pharmacology research & perspectives - 1 Jul 2018

Haage Pernilla, Kronstrand Robert, Josefsson Martin, Calistri Simona, van Schaik Ron H N, Green Henrik, Kugelberg Fredrik C

Abstract excerpt

Tramadol is a complex drug, being metabolized by polymorphic enzymes and administered as a racemate with the (+)- and (-)-enantiomers of the parent compound and metabolites showing different pharmacological effects. The study aimed to simultaneously determine the enantiomer concentrations of tramadol, O-desmethyltramadol, N-desmethyltramadol, and N,O-didesmethyltramadol following a single dose, and elucidate if...

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Identifiers

PMID: 29992026
DOI: 10.1002/prp2.419
PMCID: PMC6034060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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