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Assessment of tramadol pharmacokinetics in correlation with CYP2D6 and clinical symptoms.

Drug metabolism and personalized therapy - 29 Jun 2020

Ahmadimanesh Mahnaz, Naeini Mehri Bemani, Rouini Mohammad-Reza, Shadnia Shahin, Ghazi-Khansari Mahmoud

Abstract excerpt

Objectives Due to lack of adequate data on tramadol kinetic in relevance of CYP2D6 toxicity, this study was designed to investigate the effect of CYP2D6 phenotype in tramadol poisoning. The saliva, urine and blood samples were taken at the admission time. Consequently, concentration of tramadol and its major metabolites were measured. Methods A pharmacokinetic and metabolic study was developed in cases of...

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Identifiers

PMID: 32681776
DOI: 10.1515/dmpt-2019-0021

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