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Article

Tramadol-related fatalities: Metabolic ratios & SNPs/INDELs belonging to UGT1A8, UGT2B7, ABCC2, and SLC22A1.

Forensic science international. Genetics - 1 Mar 2025

Aly Sanaa M, Sabaouni Naoual, Hennart Benjamin, Gaulier Jean-Michel, Allorge Delphine

Abstract excerpt

Genetic polymorphism can cause variation in tramadol (TR) pharmacokinetic characteristics and the expected clinical response. In forensic toxicology, the data about parent and metabolite concentrations (MRs; metabolic ratios) could facilitate to determine the cause of death and to assess time between drug intake and death. In this study, the aim was to investigate if UGT1A8, UGT2B7, ABCC2, and SLC22A1 genotyping...

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Source

Identifiers

PMID: 39752799
DOI: 10.1016/j.fsigen.2024.103218

Genes

ABCC2
SLC22A1
UGT1A8
UGT2B7

Provenance

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