Article
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
The Biochemical journal - 9 Apr 2018
Kalogeropulou Alexia F, Zhao Jing, Bolliger Marc F, Memou Anna, Narasimha Shreya, Molitor Tyler P, Wilson William H, Rideout Hardy J, Nichols R Jeremy
Abstract excerpt
Autosomal-dominant, missense mutations in the leucine-rich repeat protein kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson's disease (PD). LRRK2 kinase activity is increased in several pathogenic mutations (N1437H, R1441C/G/H, Y1699C, G2019S), implicating hyperphosphorylation of a substrate in the pathogenesis of the disease. Identification of the downstream targets of LRRK2...
Topics
- Animals
- Cells, Cultured
- Embryo, Mammalian
- HEK293 Cells
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Neurons
- Phosphorylation
- Protein Binding