Article

Proteomics Elucidating Physiological and Pathological Functions of TDP-43

2023-05-24

Abstract excerpt

Trans-activation response DNA binding protein of 43kDa (TDP-43) regulates a great variety of cellular processes in the nucleus and cytosol. In addition, a defined subset of neurodegenerative diseases is characterized by nuclear depletion of TDP-43 as well as cytosolic mislocalization and aggregation. To perform its diverse functions TDP-43 can associate with different ribonucleoprotein complexes. Combined with tra...

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Literature Corpus work: 621b1c8e-db52-5020-868c-ff163e049b1a
DOI: 10.22541/au.168494048.81295336/v1

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