Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.

doi:10.1016/S2666-5247(24)00022-3

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Article

Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.

The Lancet. Microbe - 1 Jun 2024

Stanley Sydney, Spaulding Caitlin N, Liu Qingyun, Chase Michael R, Ha Dang Thi Minh, Thai Phan Vuong Khac, Lan Nguyen Huu, Thu Do Dang Anh, Quang Nguyen Le, Brown Jessica, Hicks Nathan D, Wang Xin, Marin Maximillian, Howard Nicole C, Vickers Andrew J, Karpinski Wiktor M, Chao Michael C, Farhat Maha R, Caws Maxine, Dunstan Sarah J, Thuong Nguyen Thuy Thuong, Fortune Sarah M

Abstract excerpt

BACKGROUND: Bacterial diversity could contribute to the diversity of tuberculosis infection and treatment outcomes observed clinically, but the biological basis of this association is poorly understood. The aim of this study was to identify associations between phenogenomic variation in Mycobacterium tuberculosis and tuberculosis clinical features. METHODS: We developed a high-throughput platform to define...

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PMID: 38734030
DOI: 10.1016/S2666-5247(24)00022-3
PMCID: PMC11229950

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