Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Asymmetric Modification of Hepatitis B Virus (HBV) Genomes by an Endogenous Cytidine Deaminase inside HBV Cores Informs a Model of Reverse Transcription.

Journal of virology - 15 May 2018

Nair Smita, Zlotnick Adam

Abstract excerpt

Cytidine deaminases inhibit replication of a broad range of DNA viruses by deaminating cytidines on single-stranded DNA (ssDNA) to generate uracil. While several lines of evidence have revealed hepatitis B virus (HBV) genome editing by deamination, it is still unclear which nucleic acid intermediate of HBV is modified. Hepatitis B virus has a relaxed circular double-stranded DNA (rcDNA) genome that is reverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-3G Deaminase
Share to Capsid
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deamination

Share to DNA, Circular

Share to Hep G2 Cells

Share to Hepatitis B virus

Share to Reverse Transcription

Source

Open in PubMed Open full text

Identifiers

PMID: 29491156
DOI: 10.1128/JVI.02190-17
PMCID: PMC5923076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asymmetric Modification of Hepatitis B Virus (HBV) Genomes by an Endogenous Cytidine Deaminase inside HBV Cores Informs a Model of Reverse Transcription.PMID 29491156Read ↗

Hepatitis B virus counters intracellular antiviral responses by saturating APOBEC/AID enzymes with rcDNASemantic proximity Read ↗

APOBEC3-induced mutation of the hepatitis virus B DNA genome occurs during its viral RNA reverse transcription into (-)-DNA.Semantic proximity Read ↗

DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNASemantic proximity Read ↗

APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription.Semantic proximity Read ↗

Deamination-Independent Inhibition of Hepatitis B Virus Reverse Transcription by APOBEC3GSemantic proximity Read ↗

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?Semantic proximity Read ↗

Mechanism of Hepatitis B Virus cccDNA FormationSemantic proximity Read ↗

Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA FormationSemantic proximity Read ↗

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA.Semantic proximity Read ↗

Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific MannerSemantic proximity Read ↗

Three novel cis-acting elements required for efficient plus-strand DNA synthesis of the hepatitis B virus genome.Semantic proximity Read ↗

Viral DNA-Dependent Induction of Innate Immune Response to Hepatitis B Virus in Immortalized Mouse HepatocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.