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APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription.

Antiviral research - 1 Jan 2018

Chen Yanmeng, Hu Jie, Cai Xuefei, Huang Yao, Zhou Xing, Tu Zeng, Hu Jieli, Tavis John E, Tang Ni, Huang Ailong, Hu Yuan

Abstract excerpt

Hepatitis B virus is a partially double-stranded DNA virus that replicates by reverse transcription, which occurs within viral core particles in the cytoplasm. The cytidine deaminase APOBEC3B is a cellular restriction factor for HBV. Recently, it was reported that APOBEC3B can edit HBV cccDNA in the nucleus, causing its degradation. However, whether and how it can edit HBV core-associated DNAs during reverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29129707
DOI: 10.1016/j.antiviral.2017.11.006

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