Three novel cis-acting elements required for efficient plus-strand DNA synthesis of the hepatitis B virus genome.

doi:10.1128/JVI.78.14.7455-7464.2004

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Article

Three novel cis-acting elements required for efficient plus-strand DNA synthesis of the hepatitis B virus genome.

Journal of virology - 1 Jul 2004

Lee Jehan, Shin Myeong-Kyun, Lee Hye-Jin, Yoon Gyesoon, Ryu Wang-Shick

Abstract excerpt

Synthesis of the relaxed-circular (RC) DNA genomes of hepadnaviruses by reverse transcriptase involves two template switches during plus-strand DNA synthesis. These template switches require repeat sequences (so-called donor and acceptor sites) between which a complementary strand of nucleic acid is transferred. To determine cis-acting elements apart from the donor and acceptor sites that are required for...

Topics

Cell Line
DNA, Circular
DNA, Viral
Enhancer Elements, Genetic
Genome, Viral
Hepatitis B virus
Humans
Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 15220419
DOI: 10.1128/JVI.78.14.7455-7464.2004
PMCID: PMC434075

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