Article
Three novel cis-acting elements required for efficient plus-strand DNA synthesis of the hepatitis B virus genome.
Journal of virology - 1 Jul 2004
Lee Jehan, Shin Myeong-Kyun, Lee Hye-Jin, Yoon Gyesoon, Ryu Wang-Shick
Abstract excerpt
Synthesis of the relaxed-circular (RC) DNA genomes of hepadnaviruses by reverse transcriptase involves two template switches during plus-strand DNA synthesis. These template switches require repeat sequences (so-called donor and acceptor sites) between which a complementary strand of nucleic acid is transferred. To determine cis-acting elements apart from the donor and acceptor sites that are required for...
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