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Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation

28 Feb 2023

Abstract excerpt

Hepatitis B virus (HBV) relies on the core protein (HBc) to establish productive infection, as defined by the formation of the covalently closed circularized DNA (cccDNA), as well as to carry out almost every step of the lifecycle following cccDNA formation. Multiple copies of HBc form an icosahedral capsid shell that encapsidates the viral pregenomic RNA (pgRNA) and facilitates the reverse transcription of pgRNA...

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PMID: 36992351
DOI: 10.3390/v15030642

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