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Article

Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States.

PloS one - 1 Jan 2021

Zeineldin Mohamed, Lehman Kimberly, Urie Natalie, Branan Matthew, Wiedenheft Alyson, Marshall Katherine, Robbe-Austerman Suelee, Thacker Tyler

Abstract excerpt

Scrapie is a slowly progressive neurodegenerative disease of small ruminants caused by an accumulation of an abnormal isoform of prion protein in the central nervous system. Polymorphisms of the prion protein gene (PRNP) strongly modulate scrapie resistance and incubation period in goats. The aim of this study was to identify PRNP genetic variability in goats across the United States. Blood from a total of 6,029...

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Identifiers

PMID: 34280230
DOI: 10.1371/journal.pone.0254998
PMCID: PMC8289333

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