Article

Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

2020-07-14

Abstract excerpt

Many cancers recruit monocytes/macrophages and polarize them into tumor-associated macrophages (TAMs). TAMs promote tumor growth and metastasis and inhibit cytotoxic T cells. Yet, macrophages can also kill cancer cells after polarization by e.g. , lipopolysaccharide (LPS, a bacteria-derived toll-like receptor 4 [TLR4] agonist) and interferon gamma (IFNγ). They do so via nitric oxide (NO), generated by inducible N...

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Literature Corpus work: 088d7508-9d30-5869-a60d-9a1795df00e5
DOI: 10.1101/2020.07.13.200477

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