Molecular determinants of permeation through the cation channel TRPV4.

doi:10.1074/jbc.M204828200

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Article

Molecular determinants of permeation through the cation channel TRPV4.

The Journal of biological chemistry - 13 Sept 2002

Voets Thomas, Prenen Jean, Vriens Joris, Watanabe Hiroyuki, Janssens Annelies, Wissenbach Ulrich, Bödding Matthias, Droogmans Guy, Nilius Bernd

Abstract excerpt

We have studied the molecular determinants of ion permeation through the TRPV4 channel (VRL-2, TRP12, VR-OAC, and OTRPC4). TRPV4 is characterized by both inward and outward rectification, voltage-dependent block by Ruthenium Red, a moderate selectivity for divalent versus monovalent cations, and an Eisenman IV permeability sequence. We identify two aspartate residues, Asp(672) and Asp(682), as important...

Topics

Amino Acid Sequence
Animals
Calcium
Cation Transport Proteins
Cells, Cultured
Humans
Ion Channels
Magnesium
Mice
Molecular Sequence Data
Mutation
Permeability
Ruthenium Red
Structure-Activity Relationship
TRPV Cation Channels

Source

Open in PubMed

Identifiers

PMID: 12093812
DOI: 10.1074/jbc.M204828200

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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