Article
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations.
Nature communications - 20 Apr 2017
Brown David, Smeets Dominiek, Székely Borbála, Larsimont Denis, Szász A Marcell, Adnet Pierre-Yves, Rothé Françoise, Rouas Ghizlane, Nagy Zsófia I, Faragó Zsófia, Tőkés Anna-Mária, Dank Magdolna, Szentmártoni Gyöngyvér, Udvarhelyi Nóra, Zoppoli Gabriele, Pusztai Lajos, Piccart Martine, Kulka Janina, Lambrechts Diether, Sotiriou Christos, Desmedt Christine
Abstract excerpt
Several studies using genome-wide molecular techniques have reported various degrees of genetic heterogeneity between primary tumours and their distant metastases. However, it has been difficult to discern patterns of dissemination owing to the limited number of patients and available metastases. Here, we use phylogenetic techniques on data generated using whole-exome sequencing and copy number profiling of...
Topics
Join the communities discussing this publication.