Article
Damage of the temporal lobe and APOE status determine neural compensation in mild cognitive impairment.
Cortex; a journal devoted to the study of the nervous system and behavior - 1 Apr 2018
Prieto Del Val Laura, Cantero Jose L, Baena Daniel, Atienza Mercedes
Abstract excerpt
In mild cognitive impairment (MCI), the APOE4 genotype is associated with accelerated memory decline, likely due to the impact of neuropathology on main cerebral networks required for successful memory retrieval and/or to decreased capacity for recruiting secondary networks that might compensate for that brain damage. Here, we tested this hypothesis in twenty-six healthy older adults and thirty-four MCI patients,...
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