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Article

Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells.

Cell reports - 20 Feb 2018

Ubaid Ullah, Andrabi Syed Bilal Ahmad, Tripathi Subhash Kumar, Dirasantha Obaiah, Kanduri Kartiek, Rautio Sini, Gross Catharina C, Lehtimäki Sari, Bala Kanchan, Tuomisto Johanna, Bhatia Urvashi, Chakroborty Deepankar, Elo Laura L, Lähdesmäki Harri, Wiendl Heinz, Rasool Omid, Lahesmaa Riitta

Abstract excerpt

Regulatory T (Treg) cells are critical in regulating the immune response. In vitro induced Treg (iTreg) cells have significant potential in clinical medicine. However, applying iTreg cells as therapeutics is complicated by the poor stability of human iTreg cells and their variable suppressive activity. Therefore, it is important to understand the molecular mechanisms of human iTreg cell specification. We...

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Identifiers

PMID: 29466736
DOI: 10.1016/j.celrep.2018.01.070
PMCID: PMC5842026

Genes

HIC1
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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