Article
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.
Cancer cell - 1 Oct 2004
Chen Wenyong, Cooper Timothy K, Zahnow Cynthia A, Overholtzer Michael, Zhao Zhiquan, Ladanyi Marc, Karp Judith E, Gokgoz Nalan, Wunder Jay S, Andrulis Irene L, Levine Arnold J, Mankowski Joseph L, Baylin Stephen B
Abstract excerpt
The gene hypermethylated in cancer 1 (HIC1) is epigenetically inactivated, but not mutated, in cancer. Here we show that cooperative loss of Hic1 with p53, but not INK4a, yields distinct tumor phenotypes in mice. Germline deletion of one allele of each gene on the opposite chromosome yields breast and ovarian carcinomas and metastatic osteosarcomas with epigenetic inactivation of the wild-type Hic1 allele....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.