Article

Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells

2024-03-12

Abstract excerpt

Human adaptive immunity is orchestrated by effector and regulatory T (Treg) cells. Natural Tregs arise in the thymus where they are shaped to recognize self-antigens, while type 1 Tregs or Tr1 cells are induced from conventional peripheral CD4 + T cells in response to peripheral antigens, such as alloantigens and allergens. Tr1 cells have been developed as a potential therapy for inducing antigen-specific toleran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24003fae-4e4a-5657-a6d6-6c4ec3de5312
DOI: 10.1101/2024.03.07.582969

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cellsDOI 10.1101/2024.03.07.582969Read

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.Semantic proximity Read

T cell factor 1: A master regulator of the T cell response in diseaseSemantic proximity Read

Single cell resolution analysis of multi-tissue derived human iNKT cells reveals novel transcriptional paradigmsSemantic proximity Read

Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease.Semantic proximity Read

Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunitySemantic proximity Read

Systems-level identification of key transcription factors in immune cell specificationSemantic proximity Read

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application.Semantic proximity Read

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscapeSemantic proximity Read

BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumorsSemantic proximity Read

Fetal Thymic Expression Defines the Immunogenicity of Tumor Associated AntigensSemantic proximity Read

Cytotoxic CD8+ Temra cells show loss of chromatin accessibility at genes associated with T cell activationSemantic proximity Read

Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunitySemantic proximity Read