Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIC1 epigenetically represses CIITA transcription in B lymphocytes.

Biochimica et biophysica acta - 1 Dec 2016

Zeng Sheng, Yang Yuyu, Cheng Xian, Zhou Bisheng, Li Ping, Zhao Yuhao, Kong Xiaocen, Xu Yong

Abstract excerpt

Differentiation of B lymphocytes into isotope-specific plasma cells represents a hallmark event in adaptive immunity. During B cell maturation, expression of the class II transactivator (CIITA) gene is down-regulated although the underlying epigenetic mechanism is not completely defined. Here we report that hypermethylated in cancer 1 (HIC1) was up-regulated in differentiating B lymphocytes paralleling CIITA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA (Cytosine-5-)-Methyltransferase 1
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3B

Share to Epigenesis, Genetic

Share to Kruppel-Like Transcription Factors

Share to Lymphocyte Activation

Share to Trans-Activators

Source

Identifiers

PMID: 27720955
DOI: 10.1016/j.bbagrm.2016.10.003

Genes

CIITA
HIC1
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIC1 epigenetically represses CIITA transcription in B lymphocytes.PMID 27720955Read ↗

Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells.Semantic proximity Read ↗

Deciphering HIC1 control pathways to reveal new avenues in cancer therapeuticsSemantic proximity Read ↗

The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.Semantic proximity Read ↗

HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and functionSemantic proximity Read ↗

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.Semantic proximity Read ↗

An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.Semantic proximity Read ↗

HIC1 Modulates Prostate Cancer Progression by Epigenetic ModificationSemantic proximity Read ↗

Epigenetic targeting of activation-induced cytidine deaminaseSemantic proximity Read ↗

An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma modelsSemantic proximity Read ↗

Loss of Hypermethylated in Cancer 1 (HIC1) in Breast Cancer Cells Contributes to Stress-induced Migration and Invasion through β-2 Adrenergic Receptor (ADRB2) MisregulationSemantic proximity Read ↗

ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing.Semantic proximity Read ↗

BMI1 regulates human erythroid self-renewal through both gene repression and gene activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.