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Article

Effect of genetic polymorphism of human CYP2B6 on the metabolic activation of chlorpyrifos.

Pesticide biochemistry and physiology - 1 Jan 2018

Imaishi Hiromasa, Goto Tatsushi

Abstract excerpt

Chlorpyrifos (CPS) is a broad-spectrum organophosphate insecticide that is neurotoxic in humans. Chlorpyrifos oxon (CPO) is a toxic metabolite of CPS that is produced by CYP2B6. In this study, we examined the variability of CPS metabolism resulting from single-nucleotide polymorphisms in CYP2B6. Wild-type CYP2B6 (CYP2B6.1) and two variants each with a single amino acid substitution: CYP2B6.5 (R487C) and CYP2B6.8...

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Identifiers

PMID: 29463407
DOI: 10.1016/j.pestbp.2017.11.003

Genes

CPO

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