Article
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2018
Shimada Tsutomu, Murayama Norie, Kakimoto Kensaku, Takenaka Shigeo, Lim Young-Ran, Yeom Sora, Kim Donghak, Yamazaki Hiroshi, Guengerich F Peter, Komori Masayuki
Abstract excerpt
1. 1-Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4 and 3A5. Catalytic differences in 1-chloropyrene oxidation by polymorphic two CYP1B1 and five CYP2A13 allelic variants were also examined. 2. CYP1A1 oxidized 1-chloropyrene at the 6- and...
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