Article
Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population.
Drug metabolism and pharmacokinetics - 1 Dec 2004
Iwasaki Masahiko, Yoshimura Yoshinobu, Asahi Satoru, Saito Kimitoshi, Sakai Shuichi, Morita Shigemichi, Takenaka Osamu, Inoda Toshio, Kashiyama Eiji, Aoyama Akinori, Nakabayashi Takeshi, Omori Satoshi, Kuwabara Takashi, Izumi Takashi, Nakamura Kouichi, Takanaka Kaoru, Nakayama Yukiharu, Takeuchi Mitsuaki, Nakamura Hideki, Kametani Shunichi, Terauchi Yoshiaki, Hashizume Takanori, Nagayama Sekio, Kume Toshiyuki, Achira Meguru, Kawai Hiroyuki, Kawashiro Takashi, Nakamura Akio, Nakai Yasuhiro, Kagayama Akira, Shiraga Toshifumi, Niwa Takuro, Yoshimura Takuya, Morita Jun, Ohsawa Fukuichi, Tani Masato, Osawa Nobuo, Ida Keiichi, Noguchi Kiyoshi
Abstract excerpt
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of single nucleotide polymorphisms (SNPs) found among the Japanese population were analyzed under a unified protocol using the same lots of reagents by the laboratories participating in the PSC. Mutations in CYP1A2, CYP2A6 and CYP2B6 were...
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