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Article

Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.

Acta neuropathologica - 1 May 2018

Labreche Karim, Kinnersley Ben, Berzero Giulia, Di Stefano Anna Luisa, Rahimian Amithys, Detrait Ines, Marie Yannick, Grenier-Boley Benjamin, Hoang-Xuan Khe, Delattre Jean-Yves, Idbaih Ahmed, Houlston Richard S, Sanson Marc

Abstract excerpt

Recent genome-wide association studies of glioma have led to the discovery of single nucleotide polymorphisms (SNPs) at 25 loci influencing risk. Gliomas are heterogeneous, hence to investigate the relationship between risk SNPs and glioma subtype we analysed 1659 tumours profiled for IDH mutation, TERT promoter mutation and 1p/19q co-deletion. These data allowed definition of five molecular subgroups of glioma:...

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Source

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Identifiers

PMID: 29460007
DOI: 10.1007/s00401-018-1825-z
PMCID: PMC5904227

Genes

TERT
IDH1
MYC
STMN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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