Article

1p19q co-deletion is an independent prognostic factor in glioma with TERT promoter mutations

2024-08-17

Abstract excerpt

<title>Abstract</title> <p>Various genetic variants, such as telomerase reverse transcriptase (TERT) promoter mutations (TERTmut) and 1p/19q co-deletion, are linked to gliomas; however, their prognostic significance remains uncertain. Here, we investigated the prevalence of TERTmut in gliomas, their correlation with clinicopathological features and molecular abnormalities, and prognostic implications of molecular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 635736d7-c1a8-54a0-b6de-bae010708ab1
DOI: 10.21203/rs.3.rs-4516259/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

1p19q co-deletion is an independent prognostic factor in glioma with TERT promoter mutationsDOI 10.21203/rs.3.rs-4516259/v1Read

Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas.Semantic proximity Read

Paradoxical prognostic impact of TERT promoter mutations in gliomas depends on different histological and genetic backgrounds.Semantic proximity Read

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.Semantic proximity Read

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss.Semantic proximity Read

TERT promoter mutation and its interaction with IDH mutations in glioma: Combined TERT promoter and IDH mutations stratifies lower-grade glioma into distinct survival subgroups-A meta-analysis of aggregate data.Semantic proximity Read

Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.Semantic proximity Read

TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations.Semantic proximity Read

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations.Semantic proximity Read

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.Semantic proximity Read

TERT promoter mutation as an independent prognostic marker in Glioblastoma: a prospective comparative studySemantic proximity Read

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes.Semantic proximity Read

A tailored next‐generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomasSemantic proximity Read