Article
Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups.
Acta neuropathologica - 1 May 2015
Weller Michael, Weber Ruthild G, Willscher Edith, Riehmer Vera, Hentschel Bettina, Kreuz Markus, Felsberg Jörg, Beyer Ulrike, Löffler-Wirth Henry, Kaulich Kerstin, Steinbach Joachim P, Hartmann Christian, Gramatzki Dorothee, Schramm Johannes, Westphal Manfred, Schackert Gabriele, Simon Matthias, Martens Tobias, Boström Jan, Hagel Christian, Sabel Michael, Krex Dietmar, Tonn Jörg C, Wick Wolfgang, Noell Susan, Schlegel Uwe, Radlwimmer Bernhard, Pietsch Torsten, Loeffler Markus, von Deimling Andreas, Binder Hans, Reifenberger Guido
Abstract excerpt
Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major challenge in terms of histological classification and clinical management. Here, we asked whether large-scale genomic and transcriptomic profiling improves the definition of prognostically distinct entities. We performed microarray-based genome- and transcriptome-wide analyses of primary tumor samples from a prospective German...
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