Article
Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.
Neuro-oncology - 1 Jun 2017
Hu Xin, Martinez-Ledesma Emmanuel, Zheng Siyuan, Kim Hoon, Barthel Floris, Jiang Tao, Hess Kenneth R, Verhaak Roel G W
Abstract excerpt
Background: Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical outcomes are observed within this category. Methods: We assembled gene expression profiles and sample annotation of 374 glioma patients carrying the 1p/19q co-deletion. We predicted 1p/19q status using gene expression when annotation was missing. A first...
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