Article
Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2013
Boots-Sprenger Sandra H E, Sijben Angelique, Rijntjes Jos, Tops Bastiaan B J, Idema Albert J, Rivera Andreana L, Bleeker Fonnet E, Gijtenbeek Anja M, Diefes Kristin, Heathcock Lindsey, Aldape Kenneth D, Jeuken Judith W M, Wesseling Pieter
Abstract excerpt
The histopathological diagnosis of diffuse gliomas often lacks the precision that is needed for tailored treatment of individual patients. Assessment of the molecular aberrations will probably allow more robust and prognostically relevant classification of these tumors. Markers that have gained a lot of interest in this respect are co-deletion of complete chromosome arms 1p and 19q, (hyper)methylation of the MGMT...
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