Article
TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations.
Acta neuropathologica communications - 23 Nov 2020
Arita Hideyuki, Matsushita Yuko, Machida Ryunosuke, Yamasaki Kai, Hata Nobuhiro, Ohno Makoto, Yamaguchi Shigeru, Sasayama Takashi, Tanaka Shota, Higuchi Fumi, Iuchi Toshihiko, Saito Kuniaki, Kanamori Masayuki, Matsuda Ken-Ichiro, Miyake Yohei, Tamura Kaoru, Tamai Sho, Nakamura Taishi, Uda Takehiro, Okita Yoshiko, Fukai Junya, Sakamoto Daisuke, Hattori Yasuhiko, Pareira Eriel Sandika, Hatae Ryusuke, Ishi Yukitomo, Miyakita Yasuji, Tanaka Kazuhiro, Takayanagi Shunsaku, Otani Ryohei, Sakaida Tsukasa, Kobayashi Keiichi, Saito Ryuta, Kurozumi Kazuhiko, Shofuda Tomoko, Nonaka Masahiro, Suzuki Hiroyoshi, Shibuya Makoto, Komori Takashi, Sasaki Hikaru, Mizoguchi Masahiro, Kishima Haruhiko, Nakada Mitsutoshi, Sonoda Yukihiko, Tominaga Teiji, Nagane Motoo, Nishikawa Ryo, Kanemura Yonehiro, Kuchiba Aya, Narita Yoshitaka, Ichimura Koichi
Abstract excerpt
TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these mutations have an impact on patient survival independent of 1p/19q codeletion is unknown. In this study, we investigated the impact of TERT promoter mutations on survival in IDH-mutated glioma cases. Detailed clinical information and molecular status data were collected for a cohort of 560 adult...
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