Article
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
The New England journal of medicine - 25 Jun 2015
Eckel-Passow Jeanette E, Lachance Daniel H, Molinaro Annette M, Walsh Kyle M, Decker Paul A, Sicotte Hugues, Pekmezci Melike, Rice Terri, Kosel Matt L, Smirnov Ivan V, Sarkar Gobinda, Caron Alissa A, Kollmeyer Thomas M, Praska Corinne E, Chada Anisha R, Halder Chandralekha, Hansen Helen M, McCoy Lucie S, Bracci Paige M, Marshall Roxanne, Zheng Shichun, Reis Gerald F, Pico Alexander R, O'Neill Brian P, Buckner Jan C, Giannini Caterina, Huse Jason T, Perry Arie, Tihan Tarik, Berger Mitchell S, Chang Susan M, Prados Michael D, Wiemels Joseph, Wiencke John K, Wrensch Margaret R, Jenkins Robert B
Abstract excerpt
BACKGROUND: The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we defined five glioma molecular groups with the use of three alterations: mutations in the TERT promoter, mutations in IDH, and codeletion of chromosome arms 1p and 19q (1p/19q codeletion). We tested the hypothesis that within groups based on...
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