Article
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Nature - 22 Feb 2018
Tauriello Daniele V F, Palomo-Ponce Sergio, Stork Diana, Berenguer-Llergo Antonio, Badia-Ramentol Jordi, Iglesias Mar, Sevillano Marta, Ibiza Sales, Cañellas Adrià, Hernando-Momblona Xavier, Byrom Daniel, Matarin Joan A, Calon Alexandre, Rivas Elisa I, Nebreda Angel R, Riera Antoni, Attolini Camille Stephan-Otto, Batlle Eduard
Abstract excerpt
Most patients with colorectal cancer die as a result of the disease spreading to other organs. However, no prevalent mutations have been associated with metastatic colorectal cancers. Instead, particular features of the tumour microenvironment, such as lack of T-cell infiltration, low type 1 T-helper cell (TH1) activity and reduced immune cytotoxicity or increased TGFβ levels predict adverse outcomes in patients...
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