Article
Frequent loss of metastatic ability in subclones of Apc, Kras, Tgfbr2, and Trp53 mutant intestinal tumor organoids.
Cancer science - 1 Apr 2023
Morita Atsuya, Nakayama Mizuho, Wang Dong, Murakami Kazuhiro, Oshima Masanobu
Abstract excerpt
Cancer evolution is explained by the accumulation of driver mutations and subsequent positive selection by acquired growth advantages, like Darwin's evolution theory. However, whether the negative selection of cells that have lost malignant properties contributes to cancer progression has not yet been fully investigated. Using intestinal metastatic tumor-derived organoids carrying Apc, Kras, Tgfbr2, and Trp53...
Topics
- Humans
- Intestinal Neoplasms
- Intestines
- Mutation
- Genes, ras
- Organoids
- Proto-Oncogene Proteins p21(ras)