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Advancing translational research for colorectal immuno-oncology

10 Aug 2023

Abstract excerpt

Colorectal cancer (CRC) is a common and deadly disease. Unfortunately, immune checkpoint inhibitors (ICIs) fail to elicit effective anti-tumour responses in the vast majority of CRC patients. Patients that are most likely to respond are those with DNA mismatch repair deficient (dMMR) and microsatellite instability (MSI) disease. However, reliable predictors of ICI response are lacking, even within the dMMR/MSI...

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PMID: 37563222
DOI: 10.1038/s41416-023-02392-x

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