Article

Aggressive <i>KRAS</i> mutations direct TGF-β response towards partial EMT in patient-derived colorectal cancer tumoroids

2024-06-29

Abstract excerpt

Transforming growth factor beta (TGF-β) exhibits complex and context-dependent cellular responses. While it mostly induces tumor-suppressive effects in early stages of tumorigenesis, its tumor promoting properties are evident in advanced disease. This TGF-β duality is still not fully understood, and whether TGF-β supports invasion and metastasis by influencing cancer cells directly, or rather through the stromal t...

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Identifiers and source

Literature Corpus work: 74ce36b6-f056-557e-a7d8-c571f1acc213
DOI: 10.1101/2024.06.25.600620

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