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Article

Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans.

The Journal of clinical endocrinology and metabolism - 1 May 2015

Todd Jennifer N, Poon Wenny, Lyssenko Valeriya, Groop Leif, Nichols Brendan, Wilmot Michael, Robson Simon, Enjyoji Keiichi, Herman Mark A, Hu Cheng, Zhang Rong, Jia Weiping, Ma Ronald, Florez Jose C, Friedman David J

Abstract excerpt

CONTEXT: Extracellular nucleotide receptors are expressed in pancreatic B-cells. Purinergic signaling via these receptors may regulate pancreatic B-cell function. OBJECTIVE: We hypothesized that purinergic signaling might influence glucose regulation and sought evidence in human studies of glycemic variation and a mouse model of purinergic signaling dysfunction. DESIGN: In humans, we mined genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25719930
DOI: 10.1210/jc.2014-4160
PMCID: PMC4422893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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