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Article

Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.

British journal of clinical pharmacology - 1 Aug 2012

McHugh Simon M, Roman Shilina, Davis Bill, Koch Annelize, Pickett Alison M, Richardson Jill C, Miller Sam R, Wetten Sally, Cox Charles J, Karpe Fredrik, Todd John A, Bullmore Edward T

Abstract excerpt

AIMS: To investigate the effects of two single nucleotide polymorphisms (SNPs) in the human P2X₇ receptor gene (P2RX7)--1068G>A (A348T) and 1513A>C (E496A)--on P2X₇ receptor function, using a specific receptor antagonist (GSK1370319A) and prospective genetic stratification. METHODS: Lipopolysaccharide- and ATP-stimulated interleukin-1β production was determined in the presence or absence of GSK1370319A in blood...

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Identifiers

PMID: 22295949
DOI: 10.1111/j.1365-2125.2012.04200.x
PMCID: PMC3630758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.PMID 22295949Read ↗

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