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Article

Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.

Molecular pain - 16 Jun 2014

Ursu Daniel, Ebert Philip, Langron Emily, Ruble Cara, Munsie Leanne, Zou Wei, Fijal Bonnie, Qian Yue-Wei, McNearney Terry A, Mogg Adrian, Grubisha Olivera, Merchant Kalpana, Sher Emanuele

Abstract excerpt

BACKGROUND: Genetic causes of exaggerated or reduced pain sensitivity in humans are well known. Recently, single nucleotide polymorphisms (SNPs) in the gene P2RX7, coding for the ATP-gated ion channel P2X7, have been described that cause gain-of-function (GOF) and loss-of-function (LOF), respecti...

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Identifiers

PMID: 24934217
DOI: 10.1186/1744-8069-10-37
PMCID: PMC4072620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24934217-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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