Article
Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.
Molecular pain - 16 Jun 2014
Ursu Daniel, Ebert Philip, Langron Emily, Ruble Cara, Munsie Leanne, Zou Wei, Fijal Bonnie, Qian Yue-Wei, McNearney Terry A, Mogg Adrian, Grubisha Olivera, Merchant Kalpana, Sher Emanuele
Abstract excerpt
BACKGROUND: Genetic causes of exaggerated or reduced pain sensitivity in humans are well known. Recently, single nucleotide polymorphisms (SNPs) in the gene P2RX7, coding for the ATP-gated ion channel P2X7, have been described that cause gain-of-function (GOF) and loss-of-function (LOF), respectively of this channel. Importantly, P2RX7 SNPs have been associated with more or less severe pain scores in patient...
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