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Article

Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.

International journal of molecular sciences - 2 Jun 2024

Lindo Jorge, Nogueira Célia, Soares Rui, Cunha Nuno, Almeida Maria Rosário, Rodrigues Lisa, Coelho Patrícia, Rodrigues Francisco, Cunha Rodrigo A, Gonçalves Teresa

Abstract excerpt

SARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic and genotypic frequencies of a...

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Source

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Identifiers

PMID: 38892324
DOI: 10.3390/ijms25116135
PMCID: PMC11173306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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